Effect of carboxylic acids on permeation of chlorpromazine through dimethyl polysiloxane membrane.
نویسندگان
چکیده
The effect of carboxylic acids on the permeation of chlorpromazine was investigated through a dimethyl polysiloxane nonpolar membrane. The permeability of the diffusate, at pH 5.8, increases considerably in the presence of carboxylic acids or phosphate, probably due to an ion-pair formation between the relative anions and chlorpromazine.
منابع مشابه
Separation of Carboxylic Acids from Aqueous Solutions using Hollow Fiber Membrane Contactors
Separation of formic, acetic, and propionic acids from the aqueous stream using membrane solvent extraction has been studied using three different membrane contactors made of polysulfone (PS), polyethersulfone (PES), and polyvinylidene fluoride (PVDF) using two different solvents; including ethyl acetate (EA) and diisopropyl ether (DIPE). The efciency of the membrane and e...
متن کاملDetermination of thermodynamic parameters of hydrogen permeation of palladium membrane for considering the effect of stainless steel support
A palladium composite membrane was prepared by electroless plating on oxidized porous stainless steel support (ox-PSS). Hydrogen permeation flux through this composite membrane was measured in the temperature range of 574-674K and the pressure difference of two sides of membrane up to 90kPa. A simplified resistance model was employed to analyze the permeation behavior of hydrogen through Pd/ox-...
متن کاملA new approach for the fabrication of microscale lipid bilayers at glass pipets: application to quantitative passive permeation visualization.
A new method of planar bilayer lipid membrane (BLM) formation is presented that allows stable, solvent-free lipid bilayers exhibiting high seal resistances to be formed rapidly, easily and reproducibly. Using these bilayers the passive permeation of a series of carboxylic acids is investigated, to determine quantitatively the trend in permeability with lipophilicity of the acid. BLMs are formed...
متن کاملStudying the effects of pH and molecular charge on the passive and iontophoretic permeation of L-phenylalanine through cellulose acetate membrane
Iontophoresis is one of the skin permeation enhancement methods involving the transport of drugs through the skin under the effect of electrical current. The effect of molecular charge on the iontophoretic permeation of drugs has not been completely understood yet. Therefore the effect of passive and iontophoretic permeation of L-phenylalanine at pH 3.6 (positive charge) and pH 8 (negative ch...
متن کاملNanostructured Palladium-Doped Silica Membrane Layer Synthesis for Hydrogen Separation: Effect of Activated Sublayers
Palladium doped silica membranes were synthesized by the sol-gel method using two different procedures. The first palladium-doped silica membrane (M1) was synthesized with a coating of four layers of silica-palladium sol. The second membrane (M2) was synthesized with a coating of two silica layers followed by a coating of two silica-palladium layers. Scanning electron microscopy (SEM) proved th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of pharmaceutical sciences
دوره 71 2 شماره
صفحات -
تاریخ انتشار 1982